Chemical Modulation of Amyloid Beta Oligomer’s in Alzheimer’s Disease
DOI:
https://doi.org/10.54536/ajcp.v4i1.4886Keywords:
Alzheimer’s Diseases, Aβ Oligomer’s, Degradation, Protein Aggregation and Condensation, StabilizationAbstract
Amyloid beta oligomers play a key role in the pathophysiology of Alzheimer’s disease. Since it contributes to memory and neuronal loss, cognitive decline, degradation of neurons as well as diseases progression. As Aβ oligomer is very small and heterogeneous and it can change from one shape to another shape therefore it has various kinds of morphologies including monomers, oligomers and fibrils. Due to instable behavior of these proteins, it’s very difficult to understand its exact mechanism. In this concise review, information over the past seven years concentrated on the molecular characteristics of amyloid-β oligomers has been summarized along with two pathways involving protein aggregation and condensation. Furthermore, metal complexes, immunotherapies, and anti-Aβ antibodies are reported here, which can modulate aggregation, stabilize non-toxic forms, and enhance degradation. Finally, new discoveries on small molecules that control, modify and inhibit the progression of amyloid-β oligomers are integrated, as these are key characteristics of Alzheimer’s disease.
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Copyright (c) 2025 Muhammad Jehangir, Sayyad Muhammad, Muhammad Tayyab, Wajid Ali, Ali Danish Alvi, Muhammad Naveed
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